I usually think of the doomsday argument as an unfortunate idea but not something that really affects my actions. It's too bad that, if the argument goes through, we have evidence against the long-term survival of humanity, but we just have to accept that fact and do the best we can to prevent human extinction against what the argument claims are tough odds.
That attitude approaches the problem from the standpoint of "causal decision theory" (CDT): Evaluating actions in terms of the causal impact that they will have to make things better. However, there's another approach, called "evidential decision theory" (EDT), which says you should do the action that, if chosen, would give you the best expectations about the outcome. While I find it far less intuitive than CDT, EDT seems to give the right answers in certain situations and so may be worth considering.
Applied to the doomsday argument, this suggests that existential-risk reducers (I'll call them "ERRs") might engage in actions that ameliorate the improbability of their being born so early in human history. For instance, if they take the relevant reference class to be the set of all lives of conscious organisms regardless of length, then ERRs could aim to extend lifespans while reducing birth rates. If the reference class includes biological humans but not post-humans, ERRs could hasten the transition to mind uploading. If the reference class is based on numbers of conscious minds, ERRs could lobby for fewer, larger post-human brains rather than disbursed post-human brains. (However, this outcome might itself be undesirable, if the utility that a single mind can experience is limited.) Obviously, the question of what reference class to use is crucial.
Even if these suggestions make theoretical sense, they aren't obviously cost-effective. It's arguably much more efficient to work on averting global catastrophes directly than to change patterns of human and post-human demographics in such a way that we'll be sufficiently less surprised by our early existence that we significantly lower our estimate of extinction risk. Is this true across the board? Or are there any purely evidential risk-reduction approaches that might be cost-effective?